PTD-DBM Peptide: Hair Studies (LONDON DAILY NEWS)

The PTD-DBM peptide is being extensively studied for its potential role in promoting hair regrowth and preventing hair follicle damage, particularly in the context of androgenetic alopecia.        

Hair follicles typically grow about half an inch per month, but external and physiological factors can damage them, leading to hair loss.

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Alopecia and Hair Loss Mechanism

Alopecia, or hair follicle loss, can be caused by hormonal changes, genetics, aging, or prolonged exposure to environmental stressors. While some hair loss is natural, excessive thinning occurs when hair regrowth slows down. Research suggests that CXXC5, a protein regulating the Wnt/β-catenin pathway (which is involved in hair regeneration and wound healing), inhibits hair follicle growth by binding to the Dishevelled (Dvl) protein.

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PTD-DBM Peptide Mechanism of Action

PTD-DBM (Product Transduction Domain-infused Dishevelled Binding Motif) is a peptide designed to block the interaction between CXXC5 and Dvl, thereby reactivating the Wnt/β-catenin signaling pathway. This process is believed to encourage hair regrowth, restore follicle elasticity, and even induce the formation of new hair follicles. Studies on bald mice treated with PTD-DBM for 28 days showed signs of new follicle formation.

Potential Benefits of PTD-DBM

Researchers believe that PTD-DBM may:

• Stimulate new hair growth
• Enhance hair follicle maturation
• Prevent follicle shrinkage
• Promote wound healing

The peptide was developed by Kang-Yeol Choi and his team after discovering that CXXC5 inhibits hair regrowth.        Early research indicates that PTD-DBM could be a promising treatment for hair loss.

Valproic Acid and PTD-DBM

Valproic acid, known for its use in treating bipolar disorder and seizures, is also being investigated for its role in activating the Wnt signaling pathway. Some studies suggest that combining PTD-DBM with valproic acid could enhance hair regrowth by further inhibiting CXXC5’s effects.

Overall, PTD-DBM shows potential as a novel approach to treating hair loss, though further research is needed to confirm its efficacy.

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 For more information, see the below original news.

London Daily News

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